The school started as Infant Jesus Grade School in 1988 with 67 pupils in primary grades. In the following years of operation, the enrollment increased which prompted the school to transfer from Pastrana Street to Roxas Avenue and then to Osmeña Avenue, Kalibo in the following years.

The old buildings were converted for vertical expansion. The right wing was named Sto. Niño Building with the first high school classrooms in the second floor completed in 1989.

With the growing number of enrollees, the school moved on to complete grade school with the first 14 graduates in 1992.

The elementary course gained recognition in 1993. To accommodate the growing population, the school transferred to its acquired site in Mabini Extension in 1993.

After several years of unstable administration, the new Board of Trustees took over the school in 1995 headed by the new President, Mrs. Merle L. Altas. To set direction for the school, the Board of Trustees requested the supervision of Jimmy Boy H. Estrellas starting 1995 until he eventually became Director in 1997. Inspired by his Lasallian Education and experience from a La Salle supervised school, he initiated improvements in facilities, curriculum, student services, discipline, religious dimension and resource mobilization with a long term master plan.

With the vision of complete basic Christian education in the year 2000, the school was granted government permit to operate secondary course starting with First Year in 1996 and was granted government recognition in 1999, a year before the first millennium graduation of batch 2000.

The other building known as St. Joseph Building was converted into three-storey with roof-top Function Hall and was completed in the summer of 2003. It was also in the same year that the school acquired part of the adjacent lot for the construction of the temporary canteen, quadrangle and basketball court. To complete the vertical expansion, another building named — the Blessed Virgin Mary Building was constructed in summer of 2006 where the present administrative offices are located, the new preschool room, computer lab, science lab, library, and AVR. The three adjoined buildings were dedicated to the Holy Family with the blessing of Holy Family Prayer Room in the roof-top area on December 2009.

The school celebrated its Silver Jubilee in 2013, renewing its commitment to serve in the next 25 years and beyond.

After the vertical expansion, the Board of Trustees has approved the Campus Development Plan for the horizontal expansion in preparation for the full implementation of the K to 12 Education Program. The construction of the new building started in 2014 and dedicated in 2016 as St. La Salle Building.

In the 30th year celebration of the school, the contruction of the covered court was initiated to become the Student Activity Center.

Infant Jesus School is now what it is today because of the continued support of parents whose dream was to provide quality Christian education for their children.